Department of Biology

Research Publications

1. Zheng X., Chen D., Zoltowski B., Sehgal A. 2024. Mitochondrial inhibitors reveal roles of specific respiratory chain complexes in CRY-dependent degradation of TIM. Sci Rep 14, 26051 (2024). https://doi.org/10.1038/s41598-024-77692-0. (corresponding author)
2. O'Hara MK, Saul C, Handa A, Cho B, Zheng X, Sehgal A, Williams JA. 2024. The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila. Sleep, 47(8):zsae096. doi: 10.1093/sleep/zsae096
3. Hsieh AL, Zheng X, Yue Z, Stine ZE, Mancuso A, Rhoades SD, Brooks R, Weljie AM, Eisenman RN, Sehgal A, Dang CV. 2019. Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism. Cell Report, 29(7):1778-1788. (co-corresponding author)
4. Stone RA, McGlinn AM, Chakraborty R, Lee DC, Yang V, Elmasri A, Landis E, Shaffer J, Iuvone PM, Zheng X, Sehgal A, Pardue MT. 2019. Altered ocular parameters from circadian clock gene disruptions. PLoS One, 14(6):e0217111
5. Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A. 2018. A Conserved Circadian Function for the Neurofibromatosis 1 Gene. Cell Report, 22 (13):3416-3426.
6. Monyak R, Emerson D, Schoenfeld B, Zheng X, Chambers D, Rosenfelt C, Langer S, Hinchey P, Choi C, McDonald T, Bolduc F, Sehgal A, McBride S, Jongens T. 2017. Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila Fragile X model. Molecular Psychiatry. 22, 1140-1148
7. Katewa SD, Rakshit K, Camarella T, Zheng X, Sehgal A, Giebultowicz J, Kapahi P. 2015. Peripheral circadian clocks modulate nutrient dependent lifespan and fat metabolism changes in Drosophila. Cell Metabolism, 23 (1):143-54.
8. Kumar S, Chen D, Jang C, Nall A, Zheng X, Sehgal A. 2014. An ecdysone-responsive nuclear receptor impacts circadian clock function in Drosophila. Nature Communication, 5:5697.
9. Zheng X, Sowcik M, Chen D, Sehgal A. 2014. Casein kinase 1 promotes synchrony of the circadian clock network. Molecular & Cellular Biology, 34 (14):2682-2694.
10. Cavanaugh DJ, Geratowski JD, Wooltorton JRA, Singh JM, Hector CE, Zheng X, Johnson EC, Eberwine JH, Sehgal A. 2014. Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell, 157 (3):689-701
11. Garbe DS, Fang Y, Zheng X, Sowcik M, Anjum R, Gygi SP, Sehgal A. 2013. Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLOS Genetics, 9 (9): e1003749.
12. Luo W, Chen WF, Yue Z, Chen D, Sowcik M, Sehgal A, Zheng X. 2012. Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell, 11 (3):428-38. (corresponding author)
13. Zheng X and Sehgal A. 2010. AKT and TOR signaling set the pace of the circadian pacemaker. Current Biology, 20 (13):1203-1208.
14. Zheng X, Koh K, Sowcik M, Smith CJ, Chen D, Wu MN, Sehgal A. 2009. An isoform specific mutant reveals essential role of PDP1 epsilon in the circadian oscillator. Journal of Neuroscience, 29 (35):10920-10927
15. Xu K, Zheng X, Sehgal A. 2008. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metabolism, 8(4):289-300
16. Sathyanarayanan S, Zheng X, Kumar S, Chen C-H, Chen D, Hay B, Sehgal A. 2008. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes & Development, 22: 1522-1533. (co-first author)
17. Zheng X, Yang Z, Yue Z, Alvarez JD, Sehgal A. 2007. FOXO and insulin signaling regulate the sensitivity of circadian clock to oxidative stress. Proceedings of the National Academy of Sciences USA, 104 (40):15899-904
18. Koh K, Zheng X, Sehgal A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science, 23; 312 (5781): 1809-12
19. Yuan Q, Lin F.J, Zheng X, Sehgal A. 2005. Serotonin modulates circadian entrainment in Drosophila. Neuron, 47 (1): 115-27
20. Sathyanarayanan S, Zheng X, Xiao R, Sehgal A. 2004. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell, 116:603-615.
21. Jaramillo AM, Zheng X, Zhou Y, Amado AD, Sheldon A, Sehgal A, Levitan I B. Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neuroscience, 5:3. (co-first author)
22. Zheng X-Z, He L-P, Geng Z-C, Zhang Y-P. 2001. Molecular evolution of the Thr-Gly region of the period gene in Drosophila and some Dipterans. Acta Genetica Sinica, 28 (3): 204-10
23. Zheng X-Z, He L-P, Geng Z-C, Zhang Y-P. 2000. Chemokine and chemokine receptor gene families - a phylogenetic study. Acta Genetica Sinica, 27 (8): 672-85
24. He L-P, Ling F-Y, Zheng X-Z, Wang W, Kuang R-P. 2000. The effect of B-chromosome on the reproduction ofalbomicans. Acta Genetica Sinica, 27 (2): 114-120
25. Zhang SM, Zhang YP, Zheng XZ, Chen YJ, Deng H, Wang DQ, Wei QW, Zhang YW, Nie L, Wu QJ. 2000. Molecular phylogenetic systematics of twelve species of Acipenseriformes based on mtDNA ND4L-ND4 gene sequence analysis. Sciences in China (C), 43 (2):129-137
26. Zheng XZ, Zhang YP, Zhu DL, Geng ZC. 1999. The period gene: high conservation of the region coding for Thr-Gly dipeptides in the Drosophila nasuta species subgroup. Journal of Molecular Evolution, 49 (3): 406-10.
27. Zheng XZ, Hong W, Yu HJ, Shao HG, Zhu DL, Geng ZC. Genetic polymorphism in natural populations of D.virilis. Acta Genetica Sinica, 26 (3): 198-202
28. Xu HF, Zheng XZ, Lu HJ. 1998. Impact of human activities and habitat changes on distribution of Chinese water deer along the coast area in Northern Jiangsu. Acta Theriologica Sinica, 18 (3): 161-167
29. Ji X, Xie YY, Sun PY, Zheng XZ. 1997. Sexual dimorphism, female reproduction in a viviparous snake, Elaphe rufodorsata. Journal of Herpetology, 31 (3): 420-422
30. Ji X, Zheng XZ, Xu YG, Sun RM. 1995. Some aspects of thermal biology of skink (Eumeces chinensis). Acta Zoologica Sinica, 41 (3): 268-274
31. Ji X, Xu YG, Zheng XZ. 1994. The major lipid reserves in the skink (Eumeces chinensis). Zoological Research, 15 (3): 59-64

 Reviews and Book Chapters

1. Zheng X. 2024. An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research. Cells, 13(14), 1192; https://doi.org/10.3390/cells13141192
2. Kayser M, Zheng X. 2013. Exploring a Role for Sleep in Neural Development and Psychiatric Disease. J Sleep Disorders Ther, 2:1. (corresponding author)
3. Shi M, Zheng X. 2013. Interactions between the circadian clock and metabolism: there are good times and bad times. Acta Biochim Biophys Sin, 45 (1):61-9. (corresponding author)
4. Zheng X, Sehgal A. 2012. Speed control: cogs and gears that drive the circadian clock. Trends in Neurosciences, 35 (9):574-85.
5. Zheng X, Sehgal A. 2008. Probing the relative importance of molecular oscillations in the circadian clock. Genetics, 178:1-9
6. Sehgal A, Joiner W, Crocker A, Koh K, Sathyanarayanan S, Fang Y, Wu M, Williams J, Zheng X. 2007. Molecular analysis of sleep:wake cycles in Drosophila. 72nd Cold Spring Harbor Symposium: Clock & Rhythms
7. Zheng XZ, Zhu DL, Geng ZC, Zhang YP. 1999. On the phylogenetic relationships of the species of the nasuta subgroup. Chinese Biodiversity, 7 (3): 226-233
8. Zheng XZ, Zhang YP, Zhu DL, Geng ZC. 1998. Molecular biology of the biological clock gene, period. Zoological Research, 19 (6): 473-481
9. Zheng XZ, Xu HF, Lu HJ. 1997. Research progress on population genetic heterogeneity. Chinese Biodiversity, 5 (3): 210-216